Antonio Sanabria scored a 94th-minute winner as Real Betis shocked Real Madrid to win at the Bernabeu in La Liga for the first time in 19 years.
Jesus Navas scored his first goal since returning to his boyhood club Sevilla, which proved to be the decisive one at the Estadio Ramon Sanchez.
Atletico Madird left San Memes with a hard fought victory as second half goals from Angel Correa and Yannick Carrasco were enough to ensure victory for Los Colchoneros despite conceding to a late Raul Garcia goal.
Real Madrid 0:1 Real Betis
Athletic Bilbao 1:2 Atlético Madrid
Leganés 0:0 Girona
Deportivo La Coruña 1:0 Alavés
Sevilla 1:0 Las Palmas