Atletico Madrid have confirmed that Kevin Gameiro, Nico Gaitan and Miguel Angel Moya have all sustained injuries at what is set to be a pivotal stage of their season.
Striker Gameiro and goalkeeper Moya have both picked up thigh problems, while Gaitan is suffering from arthritis in his toe.
All three will undergo physiotherapy treatment, with Atletico unable to put a time frame on their respective recoveries.
The news will be most unwelcome for head coach Diego Simeone, with Atleti facing a tough fixture schedule over the next two weeks.
LaLiga matches against Malaga and Real Sociedad precede a derby meeting with Real Madrid at the Santiago Bernabeu on April 8, before the Champions League quarter-final first leg against Leicester City four days later.