Juventus will take a two goal advantage into the second leg as their hosts played most of the game with 10 men.
Substitutes Marko Pjaca and Daniel Alves struck goals within two minutes of one another as Juventus punished 10-man Porto to take charge of their Champions League last-16 tie.
Porto had to play more than an hour of the game with a one man deficit as left back Alex Telles was dismissed after two bookings in a 74-second spell, the second after a wild sliding tackle on Stephan Lichtsteiner on 27 minutes.
The return leg will be played on March 14 at the Juventus Stadium.
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